Overview
This page describes the data tiers and data collection for the HTAN clinical data standard.
Description of Model
HTAN clinical data consists of four tiers. Tier 1 is in alignment with the Genomic Data Commons (GDC) guidelines for clinical data, while Tier 2, 3 and 4 are extensions to this model.
|
Tier |
Description |
|
1 |
Demographics, Diagnosis, Exposure, Treatment, Follow-up, Molecular Test and Family History |
|
2 |
Disease-agnostic extensions to the GDC |
|
3 |
Disease-specific extensions to the GDC |
|
4 |
HTAN Research Network Atlas-specific clinical data elements not covered in a previous tier and that are recognized as a requirement by the atlas. These are attributes specific to an atlas |
Tier 1 Clinical Data
To establish consistency across HTAN atlases and tumor types, the HTAN Tier 1 clinical data consists of GDC clinical data elements defined as Required, Preferred and Optional. The HTAN CDE Dictionary contains a comprehensive list of elements attributed as Required, Preferred and Optional.
Tier 2 Clinical Data
Describes disease-agnostic extensions to the GDC not included in Tier 1 Clinical Data that were suggested for inclusion by the HTAN Research Network. These suggested CDEs were compared to NCI standards described in the caDSR system and the most similar CDE was selected for inclusion in the HTAN Clinical Data model. If no comparable CDE was found for a particular element, an HTAN-specific CDE was developed.
Tier 3 Clinical Data
Describes disease-specific extensions to the GDC not included in Tier 1 Clinical Data that were suggested for inclusion by the HTAN Research Network. These suggested CDEs were compared to NCI standards described in the caDSR system and the most similar CDE was selected for inclusion in the HTAN Clinical Data model. If no comparable CDE was found for a particular element, an HTAN-specific CDE was developed.
Attributes are divided by tumor type: